Endocrine Abstracts

Introduction: Diabetes leads to skeletal fragility and an increased fracture risk. As a master regulator of bone-remodeling, osteocyte dysfunction may play a role in the pathogenesis of diabetes-related skeletal fragility. To study the effects of hyperglycemia on the osteocyte in-isolation, we used the osteocyte-like cell line IDG-SW3 taking an unbiased multi-omics-based approach.Methods: IDG-SW3 cells were plated in a differentiation osteogenic medium u...